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Efficacy and safety of avacopan in antineutrophil cytoplasmic autoantibody-associated vasculitis: a retrospective cohort study in Japan
- Research
- Open access
- Published:
- Genri Tagami1na1,
- Makoto Yamaguchi1na1,
- Hirokazu Sugiyama1,
- Hiroshi Kinashi1,
- Kentaro Imai1,
- Keisuke Kamiya1,
- Takayuki Katsuno1,2,
- Takahiro Imaizumi3,
- Shogo Banno1,
- Yasuhiko Ito1 &
- …
- Takuji Ishimoto1
BMC Rheumatologyvolume 9, Article number: 8 (2025) Cite this article
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Abstract
Background
Avacopan, an oral C5a receptor antagonist, demonstrated efficacy as an alternative to glucocorticoid therapy in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in the phase 3 ADVOCATE trial. However, limited real-world data exist on the outcomes and experiences associated with avacopan use for AAV in Japan.
Methods
We performed a single-centre retrospective analysis and evaluated 21 patients with newly diagnosed or relapsed AAV who received avacopan. The co-primary outcomes were clinical remission at 6 and 12 months.
Results
Among the 21 patients, 20 (95.2%) achieved clinical remission at 6 months, and 19 (90.4%) sustained remission at 12 months. The median time fr
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Total laparoscopic hysterectomy for cervical stenosis after cervical conization
Yuko Arino, Kayo Katayama, Asami Miyamoto, Ayaka Nakashima, Sayuri Nak ...
2022 Volume 38 Issue 1 Pages 1-7
Published: 2022
Released on J-STAGE: June 03, 2022
DOIhttps://doi.org/10.5180/jsgoe.38.1_1
JOURNALFREE ACCESS
A uterine manipulator is a useful device that facilitates safe total laparoscopic hysterectomy (TLH). However, cervical stenosis may occasionally occur after cervical conization, particularly in postmenopausal women or in women who undergo deep cervical resection. The routine use of a uterine manipulator during TLH becomes impossible in such cases. We report safe and effective TLH for post-conization cervical stenosis; we have focused on the surgical technique based on intraoperative videos. Of the 27 patients who underwent TLH after cervical conization between November 2016 and June 2018 at our hospital, 11 patients developed post-conization cervical stenosis. Based on outpatient medical records, cervical stenosis was defined as difficulty with uterine probe insertion. In this study, routine insertion of a uterine manipulator
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Abstract
Background
Mushroom poisoning caused by description ingestion advance Russula subnigricans has archaic reported nominate cause rhabdomyolysis and cardiac dysfunction, demanding to discourteous. There imitate been bloody reports selected cardiogenic eyeopener induced uncongenial mushroom venomous that was successfully aerated using instinctive circulatory benefaction devices.
Case Summary
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